What is Hepatitis C? Hepatitis C is a form of liver inflammation caused by the hepatitis C virus (HCV). The hepatitis C virus is spread worldwide and is mainly transmitted via blood. The acute disease often progresses without pronounced symptoms. However, acute hepatitis C often progresses to a chronic form. A hepatitis C infection is … Hepatitis C: Symptoms, Transmission, Therapy
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Paritaprevir was approved in many countries in 2014 in film-coated tablet form (Viekirax, combination drug). Effects Paritaprevir has antiviral properties against HCV. The effects are due to binding to the NS3/4A protease complex. HCV NS3 serine protease is an enzyme involved in viral replication. To increase availability and allow once-daily administration, paritaprevir is combined … Paritaprevir
Products Sofosbuvir is commercially available in the form of film-coated tablets (Sovaldi). It was approved in the United States and EU in 2013 and in many countries in 2014. The very high price of the drug has been a source of debate. Sofosbuvir is also combined fixed with ledipasvir (Harvoni). Cheaper generics are available in … Sofosbuvir
Focal segmental glomerulosclerosis (FSGS) is characterized by partial scarring of individual renal corpuscles. It is a group of different diseases that can lead to nephrotic syndrome in the majority of cases. Treatment depends on the underlying cause. What is focal segmental glomerulosclerosis? Focal segmental glomerulosclerosis represents a collective term for several different diseases that lead … Focal Segmental Glomerulosclerosis: Causes, Symptoms & Treatment
Interferons are tissue hormones composed of relatively short-chain polypeptides, proteins, or glycoproteins. Together with interleukins and other groups of substances, they belong to the cytokines that initiate and control the immune responses of the immune system. Interferons are produced mainly by cells of the immune system, but also by fibroblasts, and primarily control antiviral and … Interferons: Function & Diseases
Products Elbasvir was approved in many countries in 2016 as a fixed-dose combination with the protease inhibitor grazoprevir in film-coated tablet form (Zepatier). Structure and properties Elbasvir (C49H55N9O7, Mr = 882.0 g/mol) Effects Elbasvir (ATC J05AX68) has antiviral properties. The effects are due to binding to the viral protein NS5A (Non-Structural Protein 5A). Unlike other … Elbasvir
Products Dasabuvir is commercially available in the form of film-coated tablets. It was approved in many countries in 2014 (Exviera). Structure and properties Dasabuvir (C26H27N3O5S, Mr = 493.6 g/mol) has a non-nucleoside structure. It exists in the drug as a sodium salt and as a monohydrate. Effects Dasabuvir (ATC J05AX16) has antiviral properties. The effects … Dasabuvir
Products Ombitasvir was approved in the EU and many countries in 2014 in film-coated tablet form (Viekirax, combination drug). Structure and properties Ombitasvir (C50H67N7O8, Mr = 894.1 g/mol) Effects Ombitasvir (ATC J05AX66) has antiviral properties against HCV virus. The effects are due to binding to the viral protein NS5A (Non-Structural Protein 5A). Unlike other HCV … Ombitasvir
Porphyria cutanea tarda, or PCT, is the most common form of porphyria. Symptoms mainly affect the skin and liver. The disease is readily treatable, although the underlying disorder is incurable. What is porphyria cutanea tarda? Porphyria cutanea tarda is one of the so-called porphyrias and, in fact, is the most common subtype of these disorders. … Porphyria Cutanea Tarda: Causes, Symptoms & Treatment
Background It is estimated that more than 180 million people worldwide are chronically infected with the hepatitis C virus. Potential severe complications of hepatitis include cirrhosis, liver carcinoma, and liver failure. Of the various genotypes of the virus, genotype 1 in particular responds poorly to current treatment (50%). Standard drugs used include subcutaneous peginterferon alfa … Boceprevir
Condoms are aids to contraception and to avoid transmission of sexually transmitted diseases. The thin rubber sheaths are slipped over the erect penis, preventing sperm from entering the female body. Condoms are among the most popular contraceptives because they are considered relatively safe when used properly. What are condoms? Condoms are thin rubber latex sheaths … Condoms: Effect, Uses & Risks
