Products Mirabegron is commercially available in the form of sustained-release film-coated tablets (Betmiga, USA: Myrbetriq). It was approved in the US and EU in 2012 and in many countries in 2014. Mirabegron was the first agent from the beta3 agonist group to be approved for the treatment of irritable bladder. It was originally intended to … Mirabegron
Products Solifenacin is commercially available in the form of film-coated tablets (Vesicare, generics). It has been approved in many countries since 2006. Structure and properties Solifenacin (C23H26N2O2, Mr = 362.5 g/mol) is a tertiary amine and a phenylquinoline derivative that has structural similarities to atropine. It is present in drugs as (1)-(3)-solifenacin succinate, a white … Solifenacin
Products Propiverine was approved in many countries in 2020 in the form of modified-release hard capsules (Mictonorm). Later, coated tablets were also registered (Mictonet). This is an older active ingredient that was available earlier in Germany, for example. Structure and properties Propiverine (C23H29NO3, Mr = 367.5 g/mol) is present in drugs as propiverine hydrochloride. Active … Propiverine
Products Transdermal patches are approved as medicinal products. They offer themselves as an alternative to other modes of application such as peroral and parenteral administration. The first products were launched in the 1970s. Structure and properties Transdermal patches are flexible pharmaceutical preparations of varying sizes and thinness that contain one or more active ingredients. They … Transdermal Patches
Possible causes Hyperactive bladder Benign prostatic hyperplasia Urinary tract infections, e.g. cystitis Other
Products Darifenacin is commercially available in the form of sustained-release tablets (Emselex). It has been approved in many countries since 2005. Structure and properties Darifenacin (C28H30N2O2, Mr = 426.6 g/mol) is a tertiary amine. It is present in drugs as darifenacin hydrobromide, a white crystalline powder. Effects Darifenacin (ATC G04BD10) has parasympatholytic properties. It is … Darifenacin
Symptoms Acute, uncomplicated bladder infections are among the most common infectious diseases in women. A bladder infection is considered uncomplicated or simple when the urinary tract is functionally and structurally normal and there are no diseases that promote infection, for example, diabetes mellitus or immunosuppression. Symptoms include: Painful, frequent and difficult urination. Strong urge to … Cystitis: Inflammation of the Bladder
Symptoms Benign hyperplasia of the prostate is a typical and chronic age-related condition in men. Approximately 50% of men over 50 and 80% of men over 80 are affected. The incidence and symptoms increase with age. Age is therefore the most important risk factor. The clinical symptoms are also called “benign prostatic syndrome”, because the … Prostate Enlargement Causes and Treatment
Products Medicines containing Bryophyllum are commercially available as powders, drops, chewable tablets, globules, and injectable solutions (Weleda, Wala), among others. Bryophyllum was introduced into anthroposophic medicine by Rudolf Steiner in 1921. He recommended it for the treatment of hysteria. Its use as a labor inhibitor can be traced back to the German gynecologist Dr. Werner … Bryophyllum
Products Parasympatholytics are commercially available, for example, in the form of tablets, capsules, solutions, as inhalation preparations, injection solutions, and eye drops. This article refers to antagonists at muscarinic acetylcholine receptors. Antagonists at nicotinic acetylcholine receptors, such as ganglion blockers, are discussed separately. Structure and properties Many parasympatholytics are structurally derived from atropine, a natural … Parasympatholytics
Products Spasmolytics are commercially available in the form of tablets, suppositories, and injectables, among others. In many countries, scopolamine butylbromide is among the best-known representatives. Structure and properties Spasmolytics are often derived from the tropane alkaloids atropine and scopolamine from nightshade plants or from the benzylisoquinoline papaverine from the opium poppy. Effects Spasmolytics have spasmolytic … Spasmolytics
Products Fesoterodine is commercially available in the form of sustained-release tablets (Toviaz). It has been approved in the EU since 2007 and in many countries since 2008. Structure and properties Fesoterodine (C26H37NO3, Mr = 411.58 g/mol) is present in drugs as fesoterodine fumarate. It is an ester prodrug and is rapidly and completely hydrolyzed to … Fesoterodine
