Formation of mineral corticoids: Among the hormones synthesized in the zona glomerulosa are aldosterone and corticosterone. The output for the production of these hormones is cholesterol via pregnenolone and progesterone. Through further enzymatic changes (hydroxylation, oxidation) the mineral corticosteroids are finally produced. The corticosterone formed is converted to aldosterone. The receptor is located intracellularly, there … Mineral Corticoids
Formation of calcitonin: The hormone of the thyroid gland calcitonin consists of protein and is therefore a peptide hormone. In contrast to T3 – T4 hormone, this hormone is produced in the C-cells of the thyroid (parafollicular cells). The effect of this hormone unfolds on the bones, in which the bone-destroying cells (osteoclasts) are inhibited. … Calcitonin
Field of application Calcitonin is still used today in patients suffering from Paget’s disease (a disease of the skeletal system with increased and disorganized bone remodeling) who do not respond to other treatment options or for whom treatment alternatives are not suitable. One reason why other treatment would not be appropriate would be, for example, … Field of application | Calcitonin
Side effects The most frequent side effect of the administration of Calcitonin is a sudden reddening of the face. This is also known as “flush”. Other frequently occurring adverse drug reactions are a tingling sensation or a feeling of warmth in the extremities. Nausea, vomiting and diarrhoea can force a discontinuation of therapy. Hives (urticaria) … Side effects | Calcitonin
Formation of calcitriol: The steroid-like hormone calcitriol is formed from the precursor 7-dehydrocholesterol, which in turn is formed from cholesterol. The hormone passes through several stages in the course of its synthesis: First the skin under the influence of UV light, then the liver and finally the kidney. Calciol (cholecalciferol) is formed in the skin, … Calcitriol
Formation of progesterone: The hormone progesterone (corpus luteum hormone) is formed from cholesterol via pregnenolone in the corpus luteum of the ovaries, in the follicles (follicles in the ovary), in the placenta and in the adrenal cortex. Hormone production in the adrenal gland also takes place in men. The progesterone synthesis in the corpus luteum … Progesterone
Eicosanoids are hormones that act as nerve transmitters (neurotransmitters) and modulators of the immune system. These hormones are also involved in inflammatory processes. Overall, the following types of eicosanoids can be distinguished: Prostaglandins comprise a large number of subgroups, for example prostaglandin D2, prostaglandin E2, prostglandin I2 (prostacyclin) or thorboxanes. Prostaglandins Prostacyclins (part of the … Eicosanoids
Introduction The catecholamines, or catecholamines, belong to the group of hormones with androgenic effects on the cardiovascular system. The catecholamines are so-called sympathomimetic drugs, either produced by the body or artificially synthesized substances, and act on the alpha and beta receptors. Among the catecholamines are Adrenalin Noradrenaline Dopamine Isoprenalin (drug substance) Dobutamine (drug substance) Dopeaxamine … Catecholamines
Introduction The thyroid gland produces two different hormones, thyroxine (T4) and triiodothyronine (T3). The synthesis and release of these hormones is regulated by the hypothalamus and pituitary gland. Their main purpose is to increase the energy metabolism. The thyroid gland produces the hormones T3 and T4 on the one hand and calcitonin on the other. … Thyroid hormones
Transport in blood Both thyroxine (T4) and triiodothyronine (T3) are 99% bound to the thyroxine-binding globulin (TBG) in the blood. This serves to transport the hormones and prevents an early effect of T3. Only about 0.03% T4 and 0.3% T3 are present in the blood unbound and therefore biologically active. The half-life of unbound T4 … Transport in blood | Thyroid hormones
Complaints under a thyroid hormone disorder According to the functions described above: An underfunctioning of the thyroid gland (hypothyroidism), as occurs for example in the case of iodine deficiency, leads accordingly to opposite symptoms: The causes of these diseases are very different and can be congenital, autoimmune (Graves’ disease) or caused by a tumor. The … Complaints under a thyroid hormone disorder | Thyroid hormones
Summary The thyroid gland produces two important thyroid hormones, the biologically largely ineffective thyroxine (T4) and the effective triiodothyronine (T3). They are synthesized in the thyroid cells with the help of iodine and are released from the thyroid follicles as required. The effective T3 is released directly from the thyroid gland in much lower concentrations, … Summary | Thyroid hormones
