Zoledronic Acid

Products Zoledronic acid is commercially available as an infusion preparation (Zometa, Aclasta, generics). It has been approved in many countries since 2000. Structure and properties Zoledronic acid (C5H10N2O7P2, Mr = 272.1 g/mol) is present in drugs as zoledronic acid monohydrate, a white crystalline powder that is sparingly soluble in water. It is an imidazole derivative … Zoledronic Acid

Zolpidem

Products Zolpidem is commercially available as film-coated tablets, sustained-release tablets, and effervescent tablets (Stilnox, Stilnox CR, generics, USA: Ambien). It has been approved in many countries since 1990. Structure and properties Zolpidem (C19H21N3O, Mr = 307.39 g/mol) is an imidazopyridine that is structurally distinct from the benzodiazepines. It is present in drugs as zolpidem tartrate, … Zolpidem

Fence Beet

Stem plant Cucurbitaceae, fence beet. Medicinal drug Bryoniae radix – fence beet root Bryoniae radix recens – Fresh fence beet root Ingredients Cucurbitacins, among others. Effects Emetic Strongly laxative (drastic) Fields of application Obsolete, should not be used. Commission E evaluates the use negatively. Used as a laxative, emetic and diuretic in various indications in … Fence Beet

Azelaic Acid for Skin Problems

Products Azelaic acid is commercially available as gel and cream (Skinoren). It has been approved in many countries since 1990. Structure and properties Azelaic acid (C9H16O4, Mr = 188.2 g/mol) is a saturated dicarboxylic acid. It exists as a white, odorless, crystalline solid that is poorly soluble in water at 20°C but dissolves well in … Azelaic Acid for Skin Problems

Nafarelin

Products Nafarelin is commercially available as a nasal spray (Synrelina). It has been approved in many countries since 1992. Structure and properties Nafarelin (C66H83N17O13, Mr = 1322.5 g/mol) is an agonist derivative and analog of gonadotropin-releasing hormone (GnRH). It is present in the drug as nafarelin acetate. It is a decapeptide that is administered nasally … Nafarelin

Cathin

Products In many countries, there are currently no registered medicines containing the active ingredient Cathin. Products containing Cathine are not banned, but are subject to prescription and narcotics laws. Structure D-cathine (C9H13NO, Mr = 151.2 g/mol) is a natural substance from the cath (, Celastraceae), which is also produced synthetically. It is a hydroxylated amphetamine … Cathin

Rhaponti Rhubarb

Products The dry extract ERr 731 (femiLoges, formerly Phyto-Strol) from the roots of rhapontic rhubarb is commercially available in Germany in tablet form. It has not yet been approved in many countries. Medicinal drug The dried roots of rhapontic rhubarb are used as a medicinal raw material, Rhei rhapontici radix. The medicinal plant is also … Rhaponti Rhubarb

Meldonium

Products Meldonium is on the market mainly in Eastern European countries and states of the former Soviet Union in the form of capsules and as an injectable, for example in Russia, Belarus, Ukraine, and Latvia (Mildronate). However, it is not registered in many countries, in the EU and in the USA. Meldonium was developed in … Meldonium

Melphalan

Products Melphalan is commercially available in the form of film-coated tablets and as an injection/infusion preparation (Alkeran). It has been approved in many countries since 1964. Structure and properties Melphalan (C13H18Cl2N2O2, Mr = 305.2 g/mol) is a phenylalanine derivative of nitrogen-lost. It is practically insoluble in water. It exists as a pure L-enantiomer. The racemate … Melphalan

Sibutramine

Products and withdrawal from the market Sibutramine was approved in 1999 and was commercially available in many countries in 10- and 15-mg capsule form (Reductil, Abbott AG). On March 29, 2010, Abbott AG, in consultation with Swissmedic, informed the public that the marketing authorization had been suspended. Since then, sibutramine may no longer be prescribed … Sibutramine

Caroverin

Products Medicines containing Caroverin are currently no longer available in many countries. Calmavérine is out of commerce. Structure and properties Caroverin (C22H27N3O2, Mr = 365.5 g/mol) Effects Caroverin (ATC A03AX11) is spasmolytic on smooth muscle with predominantly musculotropic effects. Indications Spasms of the gastrointestinal tract, biliary tract, urinary tract, and female genital tract in dysmenorrhea. … Caroverin