Products Erdostein is commercially available in the form of capsules (Mucofor). It was developed at Edmond Pharma in Milan, Italy, and has been approved in many countries since 1994. Structure and properties Erdostein (C8H11NO4S2, Mr = 249.3 g/mol) is a prodrug. The effects are mediated by the free sulfhydryl groups (-SH) of the metabolites. The … Erdostein
Withdrawal from the market Rhinathiol Promethazine (Sanofi-Aventis Suisse SA, category C) contained a combination of the sedative antihistamine promethazine and the expectorant mucolytic carbocisteine. According to the package insert, the syrup could be taken for both productive cough and irritable cough (1). It was frequently used in children. The drug was withdrawn from the market … Rhinathiol Promethazine
Products Carbocisteine is commercially available as a syrup (e.g., rhinathiol, co-marketing drugs, generics). In combination with xylometazoline, it is also found in decongestants and nasal drops (Triofan). Structure and properties Carbocisteine or -carboxymethylcysteine (C5H9NO4S, Mr = 179.2 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a carboxymethyl derivative … Carbocistein
Products Dornase alfa is commercially available as an inhalation solution (Pulmozyme). It has been approved in many countries since 1994. Structure and properties Dornase alfa is a genetically engineered variant of the enzyme human deoxyribonuclease I, which occurs naturally in humans. Effects Dornase alfa (ATC R05CB13) has mucolytic properties. It cleaves extracellular DNA in the … Dornase Alfa
Products Expectorants are commercially available in the form of cough syrups, drops, tablets, powders, granules, pastilles, and lozenges, among others. Structure and properties Natural (herbal), semisynthetic, and synthetic agents are used. Effects Expectorants liquefy and loosen tough mucus in the respiratory tract and promote expectoration. Mucolytic: liquefy bronchial mucus. Secretolytic: promotes production of a thin … Expectorant
Mucosolvan® is a pharmacy-only drug containing the active ingredient ambroxol hydrochloride, which is used for mucolytic action in acute and chronic lung diseases and diseases of the lower respiratory tract where there is a disorder of mucus formation and mucus transport. Contraindications If hypersensitivity (allergy) to one of the ingredients of the medication is known … Mucosolvan®
Interactions If codeine is taken at the same time as Mucosolvan®, a dangerous congestion of secretion can occur due to the reduced cough reflex. The antibiotics amoxicillin, cefuroxime, doxycycline and erythromycin are increasingly absorbed into the bronchial secretion if they are taken at the same time as Mucosolvan®. Consumption during pregnancy According to studies in … Interactions | Mucosolvan®
