Presumably, the history of the opium poppy as a remedy and intoxicant drug goes back a very long time. As early as 4,000 BC, the Sumerians and Egyptians are said to have used the healing and intoxicating effects of the plant. In 1898, it was produced on a large scale and marketed as a painkiller … Heroin
Products Benzhydrocodone was approved in the United States in 2018 as a fixed combination with acetaminophen in tablet form with a modified release of active ingredient (Apadaz). Structure and properties Benzhydrocodone (C25H25NO4, Mr = 403.5 g/mol) is an inactive prodrug of hydrocodone. It is an ester of benzoic acid with the opioid that is enzymatically … Benzhydrocodone
Products Benproperine is commercially available in the form of tablets (Tussafug). The drug is not registered in many countries. Structure and properties Benproperine (C21H27NO, Mr = 309.4 g/mol) is a piperidine derivative. It is present in the drug as a racemate and benproperine phosphate. Effects Benproperine (ATC R05DB02) has antitussive properties. It is not opioid … Benproperine
Products Dextromethorphan is available in the form of tablets, lozenges, sustained-release capsules, syrup, and drops, among others (in many countries, for example, Bexin, Calmerphan, Calmesin, Pulmofor, combination preparations). The first drugs came on the market in the 1950s. Structure and properties Dextromethorphan (C18H25NO, Mr = 271.4 g/mol) was developed as an analog of codeine and … Dextromethorphan
Products Monk’s pepper extracts are commercially available as film-coated tablets and drops, among others. Stem plant Monk’s pepper L. belongs to the verbenaceae family. The shrub, which grows up to several meters high, is native to the Mediterranean region, Central Asia and India. Monk’s pepper has been used since ancient times to treat women’s ailments. … Monk Pepper
Products In many countries, no drugs containing carfentanil are on the market. The active ingredient is used in veterinary medicine (Wildnil). Legally, it belongs to narcotics. Structure and properties Carfentanil (C24H30N2O3, Mr = 394.5 g/mol) is structurally closely related to fentanyl, being 4-methoxycarbonylfentanyl. Carfentanil citrate is present in pharmaceuticals. The active ingredient was developed at … Carfentanil
Products Tramadol is commercially available in the form of tablets, capsules, melting tablets, drops, effervescent tablets, suppositories, and as a solution for injection. (Tramal, generic). Fixed combinations with acetaminophen are also available (Zaldiar, generic). Tramadol was developed by Grünenthal in Germany in 1962 and has been approved in many countries since 1977 and in the … Tramadol: Drug Effects, Side Effects, Dosage and Uses
Products The combination drug containing the active ingredients tramadol and paracetamol is commercially available in the form of film-coated tablets (Zaldiar). It has been approved in many countries since 2002. In 2014, generic versions went on sale. The effervescent tablets are out of trade. Structure and properties Tramadol (C16H25NO2, Mr = 263.38 g/mol) is a … Tramadol and Paracetamol
Products There are no medicines containing oripavine on the market in many countries. Oripavine is classified as a narcotic and requires an aggravated prescription. Structure and properties Oripavine (C18H19NO3, Mr = 297.3 g/mol) is an opioid that is structurally closely related to thebaine (3-demethylthebaine). Oripavine is an alkaloid and a natural constituent of several poppy … Oripavin
Products Cannabinoid receptor antagonists are no longer on the market in many countries. Rimonabant (Acomplia) was withdrawn from the market in 2008 because it can cause psychiatric disorders, particularly depression. Effects Cannabinoid receptor antagonists have appetite suppressant, lipid-lowering, antidiabetic, analgesic (antiallodynic, antinociceptive), and anti-inflammatory properties. The effects of cannabinoid receptor antagonists are largely opposite to … Cannabinoid Receptor Antagonists
Trade names Oxycontin®, Oxygesic Chemical name and molecular formula (5R,9R,13S,14S)-14-hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-one; C18H21NO4Oxycodone belongs to the class of strong opioid analgesics. It is used to relieve severe to very severe pain, but also has a cough-relieving effect. It is therefore also a very effective antitussive (cough-relieving drug) such as codeine. The WHO level scheme (scheme of pain … Oxycodone
Side effects As with all drugs in the class of opioid analgesics, a number of undesirable side effects can occur. First of all, it should be said that Oxycodone has a very high addiction potential, about which the patient must be informed in advance. It can lead to strong euphoria and therefore carries a high … Side effects | Oxycodone
