Psoriatic arthritis is an inflammatory disease of the joints that is usually accompanied by psoriasis. Thus, about 5 to 15 percent of those affected by psoriasis develop this form of arthritis, the underlying cause of which has not yet been determined. What is psoriatic arthritis? Psoriatic arthritis is the name given to an inflammatory disease … Psoriatic Arthritis: Causes, Symptoms & Treatment
Products Infliximab is commercially available as a powder for a concentrate for the preparation of an infusion solution (Remicade, biosimilars: Remsima, Inflectra). It has been approved in many countries since 1999. Biosimilars were released in 2015. Structure and properties Infliximab is a chimeric human murine IgG1κ monoclonal antibody with a molecular mass of 149.1 kDa … Infliximab: Drug Effects, Side Effects, Dosage and Uses
Physiotherapy is an indispensable treatment method for rheumatic diseases, including psoriasis arthritis, the inflammatory psoriasis in the joints. There are various treatment methods for psoriatic arthritis that can be used in physiotherapy. Physiotherapy is the most important way to alleviate the symptoms of psoriasis arthritis. The aim of physiotherapy is to reduce pain in the … Physiotherapy for Psoriasis-Arthritis-Psoriasis
First symptoms In 75% of people affected by psoriatic arthritis, psoriasis appears first. The first symptoms are then dry, itchy and scaly patches, which usually appear first on the elbows, knees, head, armpits, gluteal fold or breast region. The inflammatory reaction in psoriasis is triggered by the fact that cells of the immune system penetrate … First symptoms | Physiotherapy for Psoriasis-Arthritis-Psoriasis
Knee Joint The knee joint is also frequently affected by psoriatic arthritis. Those affected notice this by movement restrictions, pain and usually a significant swelling in the hollow of the knee. Here too, it is important to treat the symptoms immediately and get the inflammation under control so that it does not lead to the … Knee Joint | Physiotherapy for Psoriasis-Arthritis-Psoriasis
Summary Overall, psoriatic arthritis is an incurable disease. However, if it is detected and treated early, the affected patients have a good chance of a long painless and painless period between attacks. It is important to consult a doctor in good time if symptoms are present so that appropriate therapy can be initiated in good … Summary | Physiotherapy for Psoriasis-Arthritis-Psoriasis
Products Abatacept is commercially available as an injection and infusion preparation (Orencia). It was approved in the United States in 2005 and in the EU and many countries in 2007. Structure and properties Abatacept is a recombinant fusion protein with the following components: Extracellular domain of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Modified Fc domain of … Abatacept
Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Products Tofacitinib was approved in the United States in November 2012, in many countries in 2013, and in the EU in 2017 in film-coated tablet form (Xeljanz). The European Medicines Agency initially rejected the approval in April 2013. However, baricitinib was approved. In the United States, additional sustained-release film-coated tablets are available that are taken … Tofacitinib
Products Gold compounds are commercially available (worldwide) in the form of capsules and injection solutions (e.g., Ridaura, Tauredon), among others. They are rarely used medicinally today. Structure and properties Elemental gold (Latin: aurum, abbreviation: Au, M. r = 96.97 g/mol, atomic number 79) is a chemical element and a lustrous noble metal with a yellow … Gold
Products Prefilled methotrexate syringes have been approved in many countries since 2005 (Metoject, generic). They contain between 7.5 to 30 mg of active ingredient, in increments of 2.5 mg. The dose is much lower than for chemotherapy (“low-dose methotrexate“). The syringes are stored at room temperature between 15 to 25 °C and protected from light. … Methotrexate Ready-To-Use Syringe
Products Janus kinase inhibitors are commercially available in the form of tablets and capsules with different galenics. Structure and properties The structure of Janus kinase inhibitors is characterized by nitrogen heterocycles, which are often condensed. Effects The agents have selective immunosuppressive, anti-inflammatory, and antiproliferative properties. The effects are based on inhibition of Janus kinases (JAK). … Janus Kinase Inhibitors
