Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide
Products Octreotide is commercially available as an injectable (Sandostatin, Sandostatin LAR, generics). It has been approved in many countries since 1988. Structure and properties Octreotide is a synthetic octapeptide derivative of the hormone somatostatin. It is present in the drug as octreotide acetate and has the following structure: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol, xCH3COOH (x = 1.4 to 2.5). … Octreotide
Synonym: somatotropin-inhibitory hormone (SIH) Somatostatin is a third hormone, besides insulin and glucagon, which is produced in the pancreas. It is a messenger substance of the human body, which mainly inhibits the digestive process. It is also considered the antagonist of numerous other hormones in the body. Education Somatostatin is produced in the D-cells of … Somatostatin
Introduction Hormonal drugs are various drugs that contain hormones. Hormones are endogenous substances that are not absorbed through food. For example, there are sex hormones, thyroid hormones, pituitary hormones, pancreatic hormones such as insulin or glucagon, and adrenal hormones such as aldosterone. The most commonly used hormonal drugs contain sex hormones, either female sex hormones, … Hormonal drugs
Hormonal drugs for men Only rarely does a man have to take hormonal medication containing sex hormones. However, it is possible that a patient may produce too few male sex hormones (testosterone), for example due to castration. In this case a patient may be given hormonal medication containing the hormone testosterone. Among other things, this … Hormonal drugs for men | Hormonal drugs
Hormonal drugs in acute situations During an acute situation, such as an operation or even in the event of circulatory arrest, shock or cardiac arrest, a doctor may administer certain hormonal drugs to a patient. These are usually given (applied) via the vein, a blood vessel that usually transports blood that is low in oxygen. … Hormonal drugs in acute situations | Hormonal drugs
Products Lanreotide is commercially available as a solution for injection (Somatuline Autogel). It has been approved in many countries since 2004. Structure and properties Lanreotide is present in the drug as lanreotide acetate. It is a synthetic octapeptide analog of somatostatin with the following structure: D-βNal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2, x(CH3COOH), where x = 1 to 2 Effects Lanreotide … Lanreotide
The peptide hormone somatostatin is a hormone present in vertebrates. It is secreted by the pancreas during digestion and by the hypothalamus. Somatostatin slows the production of the growth hormone somatotropin and is considered an important regulator in the overall hormonal system. What is somatostatin? Somatostatin is a peptide hormone that plays an essential role … Somatostatin: Function & Diseases
Introduction The pancreas lies behind the peritoneum (retroperitoneal) in the upper abdomen. The pancreas has two parts, a so-called exocrine (= outward-facing) and an endocrine (= inward-facing). The exocrine part is the pancreas, i.e. a digestive juice that is released into the duodenum. The endocrine part produces the hormones insulin and glucagon and releases them … Tasks of the pancreas
Hormones of the exocrine component The main digestive enzymes found in pancreas can be divided into three major groups. Proteolytic enzymes (protein-splitting enzymes), some of which are secreted as zymogens, carbohydrate-splitting enzymes and lipolytic enzymes (fat-splitting enzymes). The most important representatives of proteases include trypsin(ogen), chymotrypsin, (pro)elastases and carboxypeptidases. These enzymes cleave proteins at different … Hormones of the exocrine component | Tasks of the pancreas
Introduction The pancreas is a gland and can be divided into two parts with regard to its microscopic structure and its function. The exogenous part is responsible for the production of digestive enzymes, while the endogenous part is essential for the production of various hormones. Structure of the pancreas The pancreas weighs about 50-120 grams, … Function of the pancreas
Function of the pancreas The pancreas has two important functions, which must be distinguished from each other. Firstly, it is the largest and most important digestive gland and secondly, it regulates the blood sugar level via the hormone insulin. As a digestive gland, the pancreas produces about 1.5 l of digestive juice (also known as … Function of the pancreas | Function of the pancreas
