Tenofovir (also tenofovirdisoproxil) is used therapeutically for HIV-1 and hepatitis B infections. Tenofovirdisoproxil is thereby activated in human cells to tenofovir. On the one hand, it inhibits reverse transcriptase in HIV viruses (or DNA polymerase in hepatitis B viruses), and on the other hand, it is incorporated into the viral DNA as a false building … Tenofovir: Effects, Uses & Risks
Products Cidofovir was initially marketed in many countries as an infusion concentrate under the brand name Vistide (Gilead). It was approved in many countries in 1997 and had not been available since 2014. In 2017, a concentrate for the preparation of an infusion solution was approved (Sidovis). Structure and properties Cidofovir (C8H14N3O6P, Mr = 279.2 … Cidofovir
Definition Drugs today usually contain a defined active pharmaceutical ingredient. However, numerous drugs with two or more active substances also exist. These are called combination drugs or fixed combinations. For example, Aspirin C contains both acetylsalicylic acid and vitamin C. Many blood pressure medications are combination preparations, for example perindopril + indapamide or candesartan + … Combination Products
Products Adefovir is commercially available in tablet form (Hepsera). It has been approved in the United States since 2002, in the EU since 2003, and in many countries since 2004. It was actually originally developed to treat HIV infection, but was not approved for that purpose. Structure and properties Adefovir is present in the drug … Adefovir
Products Didanosine was commercially available in the form of capsules (Videx EC). It was first approved in 1991 as the second HIV drug after AZT (EC = enteric coated, capsules filled with enteric granules). Structure and properties Didanosine (C10H12N4O3, Mr = 236.2 g/mol) corresponds to 2′,3′-dideoxyinosine, a synthetic nucleoside analog of deoxyadenosine. The 3′-hydroxy group … Didanosine
Products Tenofovir is commercially available in the form of film-coated tablets (Viread, combination products, generics). It has been approved in many countries since 2002. It is also used to treat chronic hepatitis B. This article refers to HIV. Structure and properties Tenofovir (C9H14N5O4P, Mr = 287.2 g/mol) is present in drugs in the form of … Tenofovir
Products Various drugs containing tenofoviralafenamide are on the market worldwide. In many countries, tenofoviralafenamide was first approved in 2016 (United States: 2015). Biktarvy: bictegravir, emtricitabine, and tenofoviralafenamide (HIV). Genvoya: elvitegravir, cobicistat, emtricitabine, and tenofoviralafenamide (HIV). Descovy: emtricitabine and tenofoviralafenamide (HIV). Odefsey: emtricitabine, rilpivirine and tenofoviralafenamide (HIV). Symtuza: darunavir + cobicistat + emtricitabine + tenofoviralafenamide. Vemlidy: … Tenofoviralafenamide