Silymarin (Milk Thistle Fruit Extract): Interactions

There are moderate interactions between silymarin and drugs that are metabolized (metabolized) in the liver via cytochromes P450 2C9. Concomitant use of silymarin and these drugs may slow their breakdown and increase their effects and side effects. Furthermore, there are interactions between milk thistle and glucuronidated drugs. In this case, the effect of the drugs … Silymarin (Milk Thistle Fruit Extract): Interactions

Silymarin (Milk Thistle Fruit Extract): Safety Evaluation

No adverse effects have been reported in clinical intervention studies conducted to date. In animal studies, oral intake of a maximum of 2,500 to 5,000 mg/kg silymarin has been shown to be nontoxic and symptom-free. Caution should be exercised in cases of hypersensitivity to the active ingredient and other plants of the genus Asteraceae (or … Silymarin (Milk Thistle Fruit Extract): Safety Evaluation

Other Vital Substances

The following are active substances (micronutrients) that also perform important tasks in the body: In addition to macronutrients (carbohydrates, proteins, fats) and the well-known vital substances – vitamins, minerals, trace elements, essential fatty acids, essential amino acids, and bioactive substances – there are numerous compounds in foods that also perform important vitamin-like functions in the … Other Vital Substances

Winter Cherry (Withania Somnifera): Safety Assessment

Because sleepberry has been used as a medicinal plant in Ayurvedic medicine for more than 3,000 years, serious toxicity is very unlikely. Low dosages were mostly used in this context. But also in the context of clinical intervention studies, no side effects have occurred and the extracts from leaves and roots used were well tolerated … Winter Cherry (Withania Somnifera): Safety Assessment

Winter Cherry (Withania Somnifera): Supply Situation

In the root of the sleeping berry, approximately 1.33% of withanolides and 0.13%-0.31% of alkaloids are present. In comparison, in the leaves, the concentrations of withanolides and alkaloids are increased by 1.8 times and 2.6 times, respectively.The extracts used in dietary supplements are usually standardized to 1.5% withanolides . The German Federal Institute for Risk … Winter Cherry (Withania Somnifera): Supply Situation

Silymarin (Milk Thistle Fruit Extract): Definition, Metabolism, Bioavailability

Silymarin is a fruit extract and comes from milk thistle (Silybum marianum). This medicinal plant belongs to the composite family (Asteraceae), subfamily Carduoideae. With a stem height of 20 cm to 150 cm, the annual to biennial herb is easily recognizable by its white-green marbled leaves and purple flower. Milk thistle grows preferentially on dry, … Silymarin (Milk Thistle Fruit Extract): Definition, Metabolism, Bioavailability

Silymarin (Milk Thistle Fruit Extract): Functions

Traditionally, silymarin has been used as a tea or dry extract to treat diseases of the liver, gallbladder, and spleen. It is now one of the best-studied phytochemicals.Based on clinical data, silymarin is used supportively for the following conditions: Alcohol-related liver disease Cirrhosis of the liver Acute and chronic hepatitis Liver disease induced by drugs, … Silymarin (Milk Thistle Fruit Extract): Functions