Melitracene and Flupentixol

Products The fixed combination Deanxit with the two active ingredients melitracene and flupentixol is commercially available in many countries in the form of film-coated tablets. The drug has been approved since 1973, initially as dragées. The marketing authorization holder is the Danish company Lundbeck. Structure and properties The active ingredients are present in the drug … Melitracene and Flupentixol

Antidepressants

Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants

Oxitriptan (5-Hydroxytryptophan)

Products Oxitriptan is not commercially available in many countries. Structure and properties Oxitriptan (C11H12N2O3, Mr = 220.2 g/mol) is a 5-hydroxy derivative of the amino acid tryptophan, the precursor of the neurotransmitter serotonin, and is also known as 5-hydroxytryptophan. Serotonin itself is not bioavailable and is therefore administered as a prodrug. Effects Oxitriptan (ATC N06AX01) … Oxitriptan (5-Hydroxytryptophan)

Aponal®

Active substance Doxepin Introduction Doxepin (trade name: Aponal®) is a drug from the group of tricyclic antidepressants. It acts in the central nervous system by inhibiting the reuptake of the neurotransmitters serotonin and noradrenalin. Doxepin has a mood-lifting and sedative (attenuating) effect. The main indication (area of application) is depression. While the damping effect starts … Aponal®

Contraindication | Aponal®

Contraindication In case of known hypersensitivity to doxepin, no application is allowed. Further contraindications are: Doxepin must also not be used while breast-feeding or in children under 12 years of age. Very cautious use in heart diseases (coronary heart disease (CHD), heart failure, cardiac arrhythmia, long QT syndrome), epilepsy, glaucoma, enlargement of the prostate (prostate … Contraindication | Aponal®