Products
Topotecan is commercially available in capsule form and as a lyophilizate (Hycamtin, generic). It has been approved in many countries since 1996.
Structure and properties
Topotecan (C23H23N3O5, Mr = 421.4 g/mol) is present in the drug as topotecan hydrochloride. It is a semisynthetic derivative of camptothecin, a plant alkaloid derived from the tree.
Effects
Topotecan (ATC L01XX17) has cytotoxic and antitumor properties. The effects are due to selective inhibition of topoisomerase I. This causes single-strand breaks in DNA, eventually leading to cancer cell death.
Indications
- Small cell bronchial carcinoma
- Metastatic ovarian cancer
- Cervical carcinoma
Dosage
According to the professional information. The drug is administered as an intravenous infusion or perorally in the form of capsules.
Contraindications
For complete precautions, see the drug label.
Interactions
Topotecan is a substrate of BCRP and P-glycoprotein. Corresponding interactions with inducers and inhibitors are possible.
Adverse effects
The most common possible adverse effects include neutropenia, anemia, thrombocytopenia, nausea, diarrhea, vomiting, hair loss, and fatigue.
