1st order laboratory parameters – obligatory laboratory tests.
- Small blood count
- Inflammatory parameters – CRP (C-reactive protein).
- Fasting glucose (fasting blood sugar)
- Blood gas analysis (BGA)
- Thyroid parameters – TSH
- Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT).
- Renal parameters – urea, creatinine, creatinine clearance if necessary.
- Coagulation parameters – PTT, Quick
- Alcohol level
- Blood type
- Blood tests to detect brain injury (if available):
- Detection of the proteins UCH-L1 (“Ubiquitin Carboxy-terminal Hydrolase-L1”) and GFAP (“Glial Fibrilliary Acidic Protein”) – the test was nevaluated in an international study of 1,947 patients who had suffered a mild to moderate disorder of consciousness (Glasgow Coma Scale 9 to 15):
- Testing was performed 3-12 hours after injury and 97.5% predicted whether lesions were later seen on CT (sensitivity). Negative CT was 99.6% predictive (negative predictive value). CONCLUSION: These results demonstrate that the test can reliably predict the absence of intracranial lesions.
- S100B test – prognostic marker after cerebral injury (apoplexy, traumatic brain injury) or neurodegeneration; if positive within 4 hours after accident → cranial computed tomography (cCT) recommendedNote: False-positive, i.e., elevated above the threshold of 0.1 ng/ml, after competitive sports, fractures, and neurological disease.
- Detection of the proteins UCH-L1 (“Ubiquitin Carboxy-terminal Hydrolase-L1”) and GFAP (“Glial Fibrilliary Acidic Protein”) – the test was nevaluated in an international study of 1,947 patients who had suffered a mild to moderate disorder of consciousness (Glasgow Coma Scale 9 to 15):
Laboratory parameters 2nd order – depending on the results of the history, physical examination and mandatory laboratory parameters – for differential diagnostic clarification.
- See with the respective differential diagnosis under laboratory diagnostics.