Trometamol

Products

Trometamol is found as an excipient in drugs, for example, in liquid and semisolid dosage forms. It should not be confused with triethanolamine (trolamine).

Structure and properties

Trometamol (C₄H₁₁NO₃, M_r = 121.1 g/mol) exists as a white crystalline powder or as colorless crystals and is readily soluble in water. It contains both hydroxyl groups and a primary amino group as functional groups. The pKa is about 8.

Effects

Trometamol has basic, emulsifying, and stabilizing properties. It is used as a base and for the preparation of buffers. Trometamol is also combined with the salt trometamol hydrochloride or hydrochloric acid for this purpose.

Indications for use

• As a pharmaceutical excipient, for example in eye drops, gels, biologics and injection solutions.
• For the production of active ingredient salts (e.g., fosfomycin, dexketoprofen, ketorolac).