1st order laboratory parameters – obligatory laboratory tests.
- Diagnostics of the pathogen should be performed in specialized laboratories (highly infectious!).
- Direct pathogen detection is difficult
- Serologically by antibody detection (AK against Francisella tularensis).
- Antigen detection (ELISA; Enzyme Linked Immunosorbent Assay), nucleic acid detection (PCR; Polymerase Chain Reaction).
Direct or indirect detection of Francisella tularensis must be reported by name if the evidence indicates acute infection (Act on the Prevention and Control of Infectious Diseases in Humans).
Second-order laboratory parameters-depending on the results of the history, physical examination, and obligatory laboratory parameters-for differential diagnostic clarification.
- Small blood count
- Inflammatory parameters – CRP (C-reactive protein) or PCT (procalcitonin).
- Blood gas analysis (BGA)
- Liver parameters – alanine aminotransferase(ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
- Renal parameters – urea, creatinine, creatinine clearance if necessary.
- Coagulation parameters – PTT, Quick
