‘Use during pregnancy and lactation
Due to insufficient experience and indications in animal experiments, the treating physician should carefully consider whether treatment with Pantozol® can be beneficial during pregnancy. Similarly critical is the use of Pantozol® during lactation.
Side effects
As a rule, Pantozol® is a well-tolerated drug. However, some side effects are known. Headaches, diarrhea, constipation, flatulence and abdominal pain are common.
Occasionally, nausea, vomiting, itching, skin rash, water retention (edema), vision disorders (blurred vision) and dizziness are reported. Rare side effects include dry mouth and joint pain. Very rarely, liver inflammation with liver damage, drop in platelets and white blood cells, hives, sensitivity to light, severe skin inflammation (erythema multiforme), Stevens-Johnsons syndrome, severe skin damage (toxic epidermal necrolysis), muscle inflammation, kidney inflammation, and depression occur.
Interactions
The simultaneous intake of Pantozol® and other, sometimes non-prescription drugs can lead to undesirable interactions. These include:
- Strengthening the effect of phenprocoumon and warfarin (blood thinner)
- Reduction of the effect of atazanavir (drug against HIV infection)
- Reduction of the effect of ketoconazole and itraconazole (preparations against fungal infections)
- Reduced absorption of vitamin B12 additives
- Reduction of the effect of Pantozol®, with simultaneous intake of drugs containing St. John’s wort
