The following are the most important diseases or complications that can be caused by endometrial carcinoma (cancer of the uterus):
Neoplasms – Tumor Diseases (C00-D48).
Metastasis
- Liver
- Lungs
- Lymph nodes
- Bones
- Overcontinuous growth into adjacent organs such as the vagina (sheath) or parametria (connective tissue structures of the pelvic cavity that extend from the wall of the cervix to the urinary bladder, the os sacrum (sacrum), and the inner lateral wall of the pelvis)
Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).
- Hematometra – accumulation of blood in the uterine cavity.
- Pyometra – accumulation of pus in the uterine cavity.
Further
- Carcinoma bleeding, which can be life-threatening (in advanced corpus carcinoma).
Prognostic factors
- Age
- Low socioeconomic status
- Longer interval between diagnosis and surgery
- Comorbidities (concomitant diseases)
- Tumor size
- Infiltration depth
- Lymph node involvement
- Metastases (daughter tumors)
- Grading (degree of tumor differentiation): high-risk subtypes include G3 endometroid carcinoma and serous endometrial carcinoma (= 30% of cases, but responsible for three-quarters of deaths)
- Platelet count (number of blood platelets) > 400,000/µl before initiation of therapy: decrease in overall survival probability as well as probability of disease-free survival; FIGO stage and metastasis (formation of daughter tumors) to lymph nodes are positively associated with thrombocytosis (number of platelets (blood platelets) in the blood is higher than normal)
