Laboratory Diagnostics
- Ca 50 is elevated in circa 45% of cases (but does not matter clinically)Note: Ca 50 may also be elevated in: Ulcerative colitis, liver cirrhosis, pancreatitis, and gastric, colon, and pancreatic cancer.
For the diagnosis of endometrial carcinoma, laboratory diagnostics play a role only in the context of histopathological and molecular diagnostic examination [S3 guideline].
| Type I carcinomas | Type II carcinomas | |
| Histological subtype | endomtriod + variants | serous, klarzelling |
| Molecular alterations | PTEN inactivationMicrosatellite instabilityβ-catenin mutationsK-ras mutations. | p53 mutationsE-cadherin- inactivationPik3Ca- alteration. |
| Molecular types | POLE ultramutated , microsatelite instability hypermutated,copy number low | Copy number high (serous like) |
Recommended cancer screening program for hereditary non-polyposis colon cancer syndrome (HNPCC)
| Age statement | Investigation | Interval |
| From the age of 25 | Physical examination | Annual |
| Colonoscopy (colonoscopy) | Annual | |
| Gynecological examination including transvaginal sonography (ultrasound examination using an ultrasound probe inserted into the vagina) | Annual | |
| From the age of 35 | Esophagogastroduodenoscopy (OGD). | Regular |
| Endometrial biopsy | Annual |
