Differentially, many diseases may be associated with pruritus vulvae. Endocrine, nutritional, and metabolic diseases (E00-E90).
- Obesity
- Diabetes mellitus
- Estrogen deficiency (especially in children, postmenopausal, lactation).
- Thyroid disease (hyper-, hypothyroidism / hyperthyroidism or hypothyroidism).
Skin and subcutaneous (L00-L99).
- Abscess
- Acne conglobata, inversa
- Allergies
- Dermatitis (inflammatory reaction of the skin)
- Eczema (vulvar eczema)
- Lichen ruber planus (nodular lichen)
- Lichen sclerosus – chronic disease of the connective tissue, which is probably one of the autoimmune diseases.
- Pemphigus vulgaris (blistering skin disease).
- Pemphigoid (blistering skin disease).
- Psoriasis (psoriasis)
- Toxic reaction
- Injury
Infectious and parasitic diseases (A00-B99).
- Pyoderma (purulent inflammation of the skin):
- Abscess (esp. Staphylococcus aureus).
- Erysipelas (bes. A streptococci).
- Erythrasma (Corynebacterium minutissimum).
- Folliculitis (Staphylococcus aureus)
- Boils and carbuncles (Staphylococcus aureus).
- Impetigo contagiosa (bork lichen; pus lichen) – by streptococci of serogroup A (GAS, group A streptococci) triggered highly infectious, not bound to the skin appendages (hair follicles, sweat glands), purulent infection of the skin (pyoderma).
- Vulvitis caused by A-streptococci (esp. in children).
- Vulvitis pustulosa (Staphylococcus aureus).
- Vulvitis plasmacellularis (unknown bacterium).
- Mycoses/fungi (esp. Candida); esp. in diabetic patients.
- Parasites:
- Endoparasites:
- Oxyurans (pinworms).
- Trichomonads
- Ectoparasites:
- Crabs (Pediculi pubis).
- Scabies (scabies)
- Endoparasites:
- Viruses
- AIDS viruses
- HPV (human papillomaviruses)
- Condyloma
- Neoplasia/preneoplasia
- Herpes viruses
- Genital herpes
- Herpes zoster
- Smallpox virus (Molluscum contagiosum)
- Varicella zoster virus (chickenpox)
Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).
- Liver diseases
Musculoskeletal system and connective tissue (M00-M99).
- Behçet’s disease (synonym: Adamantiades-Behçet’s disease; Behçet’s disease; Behçet’s aphthae) – multisystem disease of the rheumatic type associated with recurrent, chronic vasculitis (vascular inflammation) of the small and large arteries and mucosal inflammation; The triad (the occurrence of three symptoms) of aphthae (painful, erosive mucosal lesions) in the mouth and aphthous genital ulcers (ulcers in the genital region), as well as uveitis (inflammation of the middle eye skin, which consists of the choroid (choroid), the corpus ciliary (corpus ciliare) and the iris) is stated as typical for the disease; a defect in cellular immunity is suspected
Neoplasms – tumor diseases (C00-D48).
- Leukemia (blood cancer)
- Clitoral carcinoma – malignant neoplasm of the clitoris (clitoris).
- Bowen’s disease – skin disease, which belongs to the precancerous (cancer precursors).
- Hodgkin’s disease – malignant neoplasia (malignant neoplasm) of the lymphatic system with possible involvement of other organs.
- Vulvar intraepithelial neoplasia (VIN I, II, III) (precursor of vulvar carcinoma).
- Vulvar carcinoma – vulvar cancer; cancer of the external genital organs of women; median age of onset for vulvar cancer is about 70 years.
Psyche – Nervous System (F00-F99; G00-G99).
- Depression
- Partner conflict
- Psychosomatic disorders – especially in sexual conflicts (sexual disorder).
- Vaginismus (vaginismus); prevalence data vary from 4 to 42% of all women.
- Vulvodynia – discomfort and pain of the external primary genital organs lasting longer than three months without an identifiable cause; complaints are localized or generalized over the entire perineal area (tissue area between the anus and the external genital organs); may also present as a mixed form); prevalence (disease frequency) of essential vulvodynia: 1-3%.
Pregnancy, childbirth and puerperium (O00-O99).
- Infections of the genital tract during pregnancy.
- Infections of the genital tract in the puerperium
- Infections after surgical obstetric procedures (e.g. episiotomy (perineal incision), perineal tear).
Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).
- Bladder-vaginal fistula
- Urinary incontinence
- Kidney disease
- Rectal-vaginal fistula
Injuries, poisonings, and other consequences of external causes (S00-T98).
- Foreign bodies in the vulva (e.g., piercing) and vagina.
- Sexual abuse
- Special sexual practices
- Trauma/injury to the genital area (e.g., defloration (deflowering), cohabitation (coitus), masturbation, pruritus sequelae/consequences of itching (scratching, rubbing, chafing), injuries (fall, impact, instruments, and others).
Medication
- Allergic or intolerance reactions to medications (local and/or systemic).
Environmental pollution – intoxications (poisonings).
- Epithelial damage caused by:
- Chemical effects e.g. deodorants, disinfectant solutions, intimate spray vaginal rinses, ablutions.
- Maceration of the skin e.g. fluorine, fistulas, menstrual blood, sweat, secretions (urinary, fecal incontinence, carcinoma secretions).
- Mechanical irritation: e.g. tight pants, sanitary napkins, underwear.
