Products
Vatalanib is in the development phase and is not yet commercially available.
Structure and properties
Vatalanib (C20H15ClN4, Mr = 346.8 g/mol) is a chlorinated pyridine and aminophthalazine derivative. In pharmaceuticals, it is present as vatalanib succinate.
Effects
Vatalanib has antiangiogenic, antitumor, and antiproliferative properties. The effects are based on inhibition of all known VEGF receptors (vascular endothelial growth factor receptors, VEGF-R1, VEGF-R2, VEGF-R3). VEGF-R are involved in vascularization and proliferation of endothelial and tumor cells. In addition, vatalanib inhibits other kinases such as PDGF-R and c-Kit.
Indications
For the treatment of cancer.
Worth knowing
Actor Patrick Swayze (, ) was treated with vatalanib in 2008 after he was diagnosed with pancreatic cancer. The treatment also included gemcitabine.
