Very rare side effects
Acute hypersensitivity reactions, such as anaphylactic shock, are very rarely observed. If such a reaction is noticed, treatment with ibuprofen must be stopped immediately and a physician consulted in order to take appropriate medical countermeasures.
Interactions with other drugs
The active ingredient ibuprofen can have a negative effect on platelet aggregation (blood platelet function), so that patients with blood clotting disorders must be carefully monitored when treated with ibuprofen.This is also the case with therapy with anticoagulant drugs such as aspirin (ASA), in which the anticoagulant effect of the drug is then reduced by ibuprofen and blood clots can form (thrombus). If blood sugar-lowering drugs are taken at the same time as ibuprofen, ibuprofen can influence their effect and blood sugar levels should be more strictly controlled. If ibuprofen is taken over a longer period of time, it is important to check certain values regularly: If ibuprofen is taken over a longer period of time, it can lead to drug-resistant headaches. The inhibition of prostaglandin synthesis by ibuprofen can make it more difficult to become pregnant while taking ibuprofen.
- Renal function,
- Blood count
- Liver values
Side effects at a glance
- Heart Diseases Rare: palpitations, heart muscle weakness, heart attack
- Diseases of the blood and lymphatic systemVery rare: Blood formation disorders (symptoms: fever, sore throat, superficial wounds in the mouth, flu-like symptoms, severe fatigue, nosebleed, skin bleeding)
- Diseases of the nervous systemOccasionally: central nervous disorders (headaches, dizziness, insomnia, agitation, irritability, fatigue)
- Eye diseasesOccasionally: visual disorders
- Diseases of the ear and labyrinthine rarities: Noises in the ear (tinnitus)
- Diseases of the gastrointestinal tractFrequently: gastrointestinal complaints (heartburn, abdominal pain, nausea, vomiting, flatulence, diarrhoea, constipation, gastrointestinal bleeding)Occasionally: stomach/duodenal ulcers, possibly with bleeding and perforation, inflammation of the oral mucosa with ulcer formation, intensification of ulcerative colitis or Crohn’s disease, inflammation of the gastric mucosaVery rarely: inflammation of the esophagus, inflammation of the pancreas
- Diseases of the kidneys and urinary tractVery rare: increased water retention in the tissue, inflammatory kidney disease, damage to kidney tissue (increased uric acid concentrations in the blood, reduced urine excretion, general malaise)
- Diseases of the skin and subcutaneous tissueVery rare: severe skin reactions, hair loss, severe skin infections
- Infections and parasitic diseasesVery rare: worsening of infection-related inflammations, symptoms of meningitis (severe headaches, nausea, vomiting, fever, neck stiffness, clouding of consciousness) especially in autoimmune patients
- Vascular diseasesVery rare: High blood pressure
- Occasionally: hypersensitivity reactions with skin rashes and itching and asthma attacksVery rarely: severe general hypersensitivity reactions (e.g. facial edema, swelling of the tongue, internal swelling of the larynx with constriction of the airways, shortness of breath, heart palpitations, drop in blood pressure, shock)
- Liver and bile diseasesVery rare: Liver dysfunction, liver damage, liver failure, acute liver inflammation
- Psychiatric diseasesVery rare: psychotic reactions, depression
All articles in this series:
