Blood, hematopoietic organs – immune system (D50-D90).
- Sarcoidosis of the skin – sarcoidosis is a granulomatous inflammation; the disease is considered an inflammatory multisystem disorder
Skin and subcutaneous (L00-L99).
- Hypomelanosis guttata idiopathica (synonym: idiopathic hypomelanosis) – hypopigmentation likely caused by chronic UV exposure.
- Nevus depigmentosus – congenital de- or hypopigmentation (leukoderm); etiology (cause): decreased number of functionally disturbed melanocytes.
- Postinfectious hypopigmentation – hypopigmentation that may develop after infectious skin diseases such as pityriasis versicolor alba (Kleienpilzflechte with pigment loss in the epidermis; lat. alba = pale, white).
- Postinflammatory hypopigmentation – hypopigmentation that may occur after healing of various skin diseases such as chronic eczema (inflammatory changes in the skin).
Neoplasms – tumor diseases (C00-D48).
- Mycosis fungoides (T-cell non-Hodgkin’s lymphoma predominantly affecting the skin).
Further
- Acquired progressive hypomelanosis
Medication
- Toxic hypomelanosis – mainly hypopigmentation triggered by the following drugs:
- Externals containing azelaic acid
- Benzyl peroxide-containing externals
- Hydroquinone derivatives (bleaching agents)
- Externs containing kojic acid
- Topical (local) steroids
- Vitamin A derivatives
