Zieve Syndrome: Drug Therapy

Therapeutic target

  • Slowing of progression (progression).
  • Improvement of survival

Therapy recommendations

  • Drug therapy is not possible!
  • Absolute alcohol abstinence (abstaining from alcohol).
  • Adequate nutrition (with positive nitrogen balance).
  • Intensive therapy if necessary
  • For alcoholic hepatitis, the following agents can be used (see below).
  • In the final stages of cirrhosis, liver transplantation (LTx) may be considered.
Active ingredient group

Active ingredients Special features
Glucocorticoids Prednisone

Therapy for 4 weeks, then taper off
Success under glucocorticoids is evident when serum bilirubin drops 25% within the first 6-9 days
TNF-α inhibitor

Infliximab Risk of reactivation of tuberculosis