Products Isosorbide dinitrate is commercially available in many countries in the form of tablets, sustained-release tablets, sustained-release capsules, as an infusion concentrate, and as a spray (Isoket). The drug first came on the market in the 1940s. Structure and properties Isosorbide dinitrate (C6H8N2O8, Mr = 236.14 g/mol) exists as a white, fine, crystalline and odorless … Isosorbide Dinitrate
Products Isosorbide mononitrate was commercially available in the form of divisible extended-release tablets (Corangin). It was approved in many countries in 1987 and was withdrawn from the market in 2014. Other nitrates can be used as substitutes, such as isosorbide dinitrate. Structure and properties Isosorbide mononitrate (C6H9NO6, Mr = 191.1 g/mol) is an organic nitrate. … Isosorbide Mononitrate
Products Nitrates are commercially available in the form of chewable capsules, transdermal patches, infusion preparations, ointment, sustained-release tablets, sustained-release capsules, and sprays. As the first representative, nitroglycerin was already produced in the 19th century and used for the treatment of angina pectoris. Nitrates are thus among the oldest synthetic drugs. Structure and properties Organic nitrates … Organic Nitrates
Background Phenylalanine is an essential amino acid that is not produced by the human organism itself. Phenylalanine ingested with food is produced by the enzyme phenylalanine hydroxylase and its cofactor 6-tetrahydrobiopterin (6-BH4) metabolized to tyrosine. Phenylketonuria is an autosomal recessive disorder caused by insufficient activity of phenylalanine hydroxylase, resulting in elevated blood phenylalanine levels, i.e., … Sapropterin
