Plavix

Synonyms Clopidogrel Definition Plavix®(clopidogrel) is used as a drug and belongs to the group of antiplatelet aggregation inhibitors. It thus prevents blood from clotting and thus prevents the formation of thrombi (blood clots), which potentially lead to embolism (complete dislocation of blood vessels), which can result in a pulmonary embolism or stroke, for example, and … Read more

Pharmacokinetics and dynamics | Plavix

Pharmacokinetics and dynamics Plavix® (clopidogrel) is a prodrug, which means that it is only converted into its active form in the organism (i.e. after administration). It takes 5-7 days before its full anticoagulant effect sets in. Although its physical half-life is only 7-8 hours, its effect lasts much longer. It is excreted in approximately equal … Read more

Related drugs | Plavix

Related drugs Ticlopidine – it uses the same mechanism of action as Plavix® (clopidogrel), but has been largely ousted by its partner with fewer side effects due to the possible development of severe leukopenia (a sharp drop in white blood cell count) as a side effect Abciximab, eptifibatide, tirofiban – they also inhibit primary hemostasis, … Read more

Apixaban

Products Apixaban has been approved in many countries since 2011 in the form of film-coated tablets (Eliquis). Structure and properties Apixaban (C25H25N5O4, Mr = 460.0 g/mol) was developed starting from razaxaban. It is an oxopiperidine and pyrazole derivative. Effects Apixaban (ATC B01AF02) has antithrombotic properties. It is an oral, direct, potent, selective, and reversible inhibitor … Read more

Effect of Marcumar®

Synonyms in a broader sense Phenprocoumon (active ingredient name), coumarins, vitamin K antagonists (inhibitors), anticoagulants, anticoagulants How does Marcumar® work? The drug known under the trade name Marcumar® contains the active ingredient phenprocoumon, which belongs to the main group of coumarins (vitamin K antagonists). The coumarins are molecules that have a suppressive effect on the … Read more

Side effects | Effect of Marcumar®

Side effects Unwanted side effects cannot be ruled out, often accompanying symptoms such as nausea, vomiting, stomach pain, loss of appetite and diarrhoea occur. In some patients, long-term treatment with Marcumar® resulted in constipation, increased hair loss, the appearance of bruising and even undesirable bleeding tendencies. Particularly serious side effects include intracranial bleeding (intracerebral bleeding, … Read more

Mono-Embolex

Introduction Mono-Embolex® is a so-called anticoagulant, i.e. a drug that inhibits blood coagulation (anticoagulant) and is thus used primarily for the prophylaxis and therapy of venous thrombosis and pulmonary embolism. The active ingredient of the preparation Mono-Embolex® is certoparin sodium. The active ingredient Certoparin belongs to the class of low molecular weight (=fractionated) heparins. These … Read more

Fields of application | Mono-Embolex

Fields of application Low molecular weight heparins such as the active ingredient certoparin in Mono-Embolex® are suitable for thrombosis prophylaxis and thrombosis therapy. Thrombosis is a disease that occurs in the blood vessels. A blood clot is formed via the coagulation cascade, which closes the blood vessel. Often thromboses are localized in the veins and … Read more

Therapy monitoring | Mono-Embolex

Therapy monitoring In contrast to a standard heparin, the fluctuations of the drug level in the body are significantly lower with low-molecular-weight heparin. For this reason, therapy monitoring is usually not absolutely necessary. Exceptions are patients who have an increased risk of bleeding and/or patients who suffer from renal insufficiency. In such cases, the determination … Read more

Pregnancy and lactation | Mono-Embolex

Pregnancy and lactation There is a lot of experience regarding the use of low molecular weight heparins in pregnancy. In the first 12 weeks of pregnancy, no harmful effect on the embryo could be observed when using Mono-Embolex®. This finding is based on approximately 2,800 observed pregnancies under Certoparin therapy. Mono-Embolex® does not appear to … Read more

Nutrition when taking Marcumar

Synonyms in a broader sense Phenprocoumon (active ingredient name), coumarins, vitamin K antagonists (inhibitors), anticoagulants, anticoagulantsThe drug known under the trade name Marcumar® contains the active ingredient phenprocoumon, which belongs to the main group of coumarins (vitamin K antagonists). The coumarins are molecules that have a suppressive effect on the natural processes of blood coagulation … Read more