Products
Vedaprofen was commercially available as a gel for administration to horses (Quadrisol). It was approved in many countries in 1996 and was withdrawn from the market in 2012.
Structure and properties
Vedaprofen (C19H22O2, Mr = 282.4 g/mol) is an arylpropionic acid derivative present in the drug as a racemate. It is structurally related to naproxen.
Effects
Vedaprofen (ATCvet QM01AE90) is analgesic, anti-inflammatory, and antipyretic. The effects are due to inhibition of cyclooxygenase and thus prostaglandin synthesis. The half-life is 6 to 8 hours.
Indications
Vedaprofen is used in horses to treat pain and inflammation.
Dosage
According to the product information. The gel has a pleasant taste and is administered perorally twice daily before feeding.
Contraindications
Vedaprofen is contraindicated in diseases of the digestive tract, impaired cardiac, hepatic or renal function, foals up to 6 months of age, mucosal lesions in the mouth, dehydrated, hypovolemic and hypotensive horses. Refer to the drug label for complete precautions.
Interactions
Drug-drug interactions are possible with other NSAIDs, diuretics, drugs with high protein binding, and glucocorticoids.
Adverse effects
Possible adverse effects include mucosal lesions, digestive bleeding, diarrhea, urticaria, listlessness, and loss of appetite.