Products
Clascoterone was approved as a cream in the United States in 2020 (Winlevi).
Structure and properties
Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water.
Effects
Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens such as dihydrotestosterone are associated with the development of acne.
Indications
For the treatment of acne vulgaris (acne) starting at age 12 years.
Dosage
According to the professional information. After cleansing the skin, the cream is applied thinly in the morning and evening.
Contraindications
- Hypersensitivity
- Pregnancy and lactation
Full precautions can be found in the drug label.
Adverse effects
The most common possible adverse effects include local reactions such as skin redness, itching, scaling, and dry skin. Especially when used inappropriately (high dose, large surface area, occlusion), the hypothalamic-pituitary axis may be suppressed.
