Products
Dembrexin is commercially available as a powder for administration with feed as a veterinary drug. It has been approved in many countries since 1988.
Structure and properties
Dembrexin (C13H17Br2NO2, Mr = 379.1 g/mol) is a benzylamine. It is structurally closely related to bromhexine (e.g., bisolvone) and ambroxol (e.g., mucosolvone) and is present in the drug as dembrexine hydrochloride monohydrate. Bromhexine is derived from vasicin, an herbal ingredient from the Indian medicinal plant .
Effects
Dembrexin (ATC QR05CB90) is secretolytic and secretomotor. It liquefies mucus and facilitates expectoration of viscous secretions.
Indications
For symptomatic treatment of obstructive airway diseases in horses.
Dosage
According to the package insert. Dembrexin is administered orally twice daily with feed. The duration of treatment should not exceed 15 days.
Contraindications
Dembrexin is contraindicated in hypersensitivity, incipient pulmonary edema, and renal and hepatic impairment. For complete precautions, see the drug label.
Interactions
There are no known drug-drug interactions.
Adverse effects
No adverse effects have been described. Bromhexine is known to cause gastric irritation and allergic reactions.
