Fludrocortisone Acetate

Products

Fludrocortisone acetate is commercially available as tablets and ear drops (Florinef, Panotile). It has been approved in many countries since 1964.

Structure and properties

Fludrocortisone acetate (C₂₃H₃₁FO₆, M_r = 422.5 g/mol) is white crystalline powder that is practically insoluble in water.

Effects

Fludrocortisone acetate (ATC H02AA02) is mineralocorticoid with glucocorticoid component of action.

Indications

• Substitution therapy for marked adrenocortical insufficiency, especially Addison’s disease.
• Salt wasting syndrome in adrenogenital syndrome.
• Otitis externa