Leg Swelling (Leg Edema): Diagnostic Tests

Obligatory medical device diagnostics.

  • Compression phlebosonography (KUS, synonym: vein compression sonography); sonography (ultrasound examination) to document and check the compressibility of the deep veins in the legs and arms) – in cases of suspected deep vein thrombosis (DVT); very safe procedure especially in cases of thrombi of the femoral veins or popliteal vein [gold standard].
  • Color-coded duplex sonography – to exclude leg vein thrombosis and in cases of suspected thrombi in the hollow/pelvic veins.
  • Pulse oximetry (procedure for non-invasive determination of arterial oxygen saturation (SpO2) via measurement of light absorption).

Optional medical device diagnostics – depending on the results of the history, physical examination and mandatory laboratory parameters – for differential diagnostic clarification.

  • Doppler sonography (color-coded duplex sonography)* – ultrasound procedure, which can assess in particular the blood flow in the vessels.
  • Echocardiography (either transthoracic/through the chest or transesophageal/through the esophagus) – for suspected heart failure (cardiac insufficiency).
  • Electrocardiogram (ECG)
  • Stress ECG
  • X-ray chest – to detect myocardial enlargement (dilatation?), pulmonary congestion or pulmonary edema.
  • Phlebography (imaging of veins by contrast administration in conventional X-ray) – indicated in sonographically unclear findings.
  • Venous occlusion plethysmography – indicated for course assessment, if necessary.
  • Magnetic resonance phlebography (MR phlebography) – indicated for suspected abdominal/pelvic thrombi.
  • Ascending press phlebography – prior to surgical therapy [gold standard].
  • Sonography (ultrasound examination) of the affected body region – to assess tissue changes.
    • Abdominal ultrasonography (ultrasound of abdominal organs) – in the first days after presentation [neoplasia (new growth)?; lymph nodes in the abdominopelvic region; examination of liver, spleen, and kidneys]
    • Liver sonography (ultrasound of the liver) – if cirrhosis (irreversible (non-reversible) damage to the liver and a marked remodeling of liver tissue) is suspected.
    • Renal sonography (ultrasound of the kidneys) – when renal insufficiency (kidney weakness) is suspected.
  • Isotope lymphography – shows the functional status of the lymphatic system.
  • Magnetic resonance lymphangiography – to visualize the lymphatic vessels with the help of contrast medium.
  • Indirect lymphography – imaging of a specific segment; implementation only possible off label.
  • Fluorescence microlymphography (using fluorescence microlymphography, the initial skin lymphatic vessels can be visualized in a minimally invasive way and their function can be analyzed) – to determine the morphology of the lymphatic capillaries.
  • Computed tomography (CT) or magnetic resonance imaging (MRI) – to exclude tumor disease.
  • Light reflection rheography – for suspected chronic venous insufficiency (CVI).

* Caution. Lipedema and venous insufficiency (chronic venous congestion syndrome, CVI)/varicosis (varicose veins) have a very high coincidence (coincidence, -meeting of two events), so that the venous status – in the sense of a differential diagnosis – should be clarified by duplex sonography. Under the guise of lipedema, for example, postthrombotic syndrome (PTS) may also be hidden.