Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide
Onychauxis is a disease that affects the nails of fingers and toes. The name of the disease is derived from the Greek language, where it comes from the terms ‘onyx’ for fingernail and ‘auxano’ for proliferation. Onychauxis is present in affected individuals either from birth or is acquired during the rest of life due to … Onychauxis: Causes, Symptoms & Treatment
Products Octreotide is commercially available as an injectable (Sandostatin, Sandostatin LAR, generics). It has been approved in many countries since 1988. Structure and properties Octreotide is a synthetic octapeptide derivative of the hormone somatostatin. It is present in the drug as octreotide acetate and has the following structure: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol, xCH3COOH (x = 1.4 to 2.5). … Octreotide
Acromegaly is a rare metabolic disorder that causes excessive growth of limbs. Acromegaly means something like “enlargement of the outermost parts of the body.” Affected individuals have very large ears, nose, hands and feet. The cause is a brain tumor that leads to overproduction of a growth hormone. Acromegaly can be inherited through gene mutations. … What is Acromegaly?
The bite position provides information about the sagittal positional relationship between the lower jaw and the upper jaw. In a neutral bite position, both jaws are in the correct relation to each other. What is the bite position? Bite position is a positional designation that provides information about how the two jaw bones relate to … Bite Position: Function, Tasks, Role & Diseases
The pituitary gland, in German Hirnanhangsdrüse, is a hormonal gland about the size of a hazelnut seed, located at the level of the nose and ears in the middle cranial fossa. It works closely with the hypothalamus and, like an interface between the brain and bodily processes, controls the release of vital hormones that influence … Pituitary Gland: Structure, Function & Diseases
Products Pegvisomant is commercially available as a powder and solvent for the preparation of a solution for injection (Somavert). It has been approved in many countries since 2005. Structure and properties Pegvisomant is a derivative of human growth hormone produced by biotechnological methods. It consists of 191 amino acids and is pegylated at several sites. … Pegvisomant
Definition Acromegaly refers to a pathological change in growth due to chronic somatotropin excess. The condition occurs primarily in individuals aged 40-50 years. If acromegaly is not adequately treated, life expectancy is shortened by approximately 10 years due to secondary diseases. Symptoms The symptoms of acromegaly initially remain inconspicuous. The symptoms are nonspecific and develop … Acromegaly: Too Much Growth Hormone
Products Bromocriptine is commercially available in tablet form (Parlodel). It was developed at Sandoz in the 1960s and has been approved in many countries since 1975. Generic versions are now available in many countries. Structure and properties Bromocriptine (C32H40BrN5O5, Mr = 654.6 g/mol) is a brominated derivative of the natural ergot alkaloid ergocryptine. It is … Bromocriptine
Bromocriptine is an active substance that belongs to the group of ergot alkaloids. The active ingredient is used primarily if there is a disease that is due to too high a level of prolactin in the blood. What is bromocriptine? Because of its special properties, bromocriptine is used to treat health problems and diseases that … Bromocriptine: Effects, Uses & Risks
Patients with Carney complex are conductively symptomatic of hormonal imbalances and myxomas. The disease is a mutation-related inherited disorder. Treatment is supportive symptomatic and primarily involves surgical removal or monitoring of myxomas and other tumors. What is a Carney complex? So-called myxomas are benign tumors composed of unformed connective tissue and mucinous gelatinous substance. The … Carney Complex: Causes, Symptoms & Treatment
In hyperostosis, bone tissue increases. The culprit is usually increased activity of osteoblasts. Drug treatment options are now available for treatment in addition to curettage. What is hyperostosis? In hyperplasia, a tissue or organ enlarges by increasing its cell count. This increase in cell number is usually a response to functionally increased stress or hormonal … Hyperostosis: Causes, Symptoms & Treatment
