Introduction Breast cancer resistance protein (BCRP or ABCG2) is an efflux transporter that belongs to the ABC superfamily (ATP-binding cassette). It is encoded by the gene first isolated from breast cancer cells in 1998. BCRP consists of 655 amino acids and has a molecular weight of 72 kDa. BCRP mediates resistance to structurally and pharmacologically … BCRP
Products Paclitaxel is commercially available as an infusion concentrate (Taxol, generic). It has been approved in many countries since 1993. The active ingredient itself is also known as taxol. Protein-bound nab-paclitaxel (Abraxane) was approved in many countries in 2014. Structure and properties Paclitaxel (C47H51NO14, Mr = 853.9 g/mol) is a complex tetracyclic diterpene. It exists … Paclitaxel
