Products Dimethyl fumarate is commercially available in the form of capsules with enteric-coated microtablets (Tecfidera). It has been approved in many countries since 2014. Dimethyl fumarate is also approved for the treatment of psoriasis (Skilarence). This article is related to MS therapy. In 2019, a new prodrug of the active ingredient was approved; see diroximelfumarate … Dimethyl Fumarate
Introduction Tecfidera® is a drug that is mainly used for the treatment of multiple sclerosis. Multiple sclerosis is a nervous disease of the chronic inflammatory type. In the course of this disease, the myelin sheaths of the nerves in the central nervous system (CNS) are gradually destroyed. Myelin sheaths are the layer of lipids (fat, … Tecfidera
Application areas Tecfidera® has two main areas of application. Firstly, it is used in multiple sclerosis and secondly, a chemically very similar fumaric acid under the name Fumaderm® is used in psoriasis. In the therapy of multiple sclerosis, the main focus during the application of Tecfidera® is on the reduced number of attacks. Like multiple … Application areas | Tecfidera
Interactions Interactions occur with Tecfidera® above all when the other drug taken has a nephrotoxic effect (toxic to the kidneys). Since Tecfidera® also sometimes causes side effects on the kidneys, the combination of two nephrotoxic drugs could result in severe kidney damage and, in the worst case, kidney failure. Drugs that burden the kidneys include … Interactions | Tecfidera
