Fumarates

Dimethyl Fumarate

Products Dimethyl fumarate is commercially available in the form of capsules with enteric-coated microtablets (Tecfidera). It has been approved in many countries since 2014. Dimethyl fumarate is also approved for the treatment of psoriasis (Skilarence). This article is related to MS therapy. In 2019, a new prodrug of the active ingredient was approved; see diroximelfumarate … Dimethyl Fumarate

Diroximelfumarate

Products Diroximelfumarate was approved in the United States in 2019 in the form of sustained-release capsules (Vumerity). It should not be confused with dimethyl fumarate (Tecfidera). Structure and properties Diroximelfumarate (C11H13NO6, Mr = of 255.2 g/mol) exists as a white powder that is sparingly soluble in water. The active metabolite monomethyl fumarate (MMF, see below) … Diroximelfumarate