Dopamine Antagonists

Effects Dopamine antagonists are antidopaminergic, antipsychotic, antiemetic, and prokinetic. They are antagonists at dopamine receptors, eg, dopamine (D2)-receptors, thus abolishing the effects of the neurotransmitter dopamine. Indications Psychotic disorders Nausea and vomiting, to promote gastric emptying and motility in the gastrointestinal tract. Some dopamine antagonists are also used to treat movement disorders (dyskinesias, including neuroleptic-induced), … Dopamine Antagonists

Tetrabenazine

Products Tetrabenazine is commercially available in tablet form (Xenazine). It has been approved in many countries since 2008. Structure and properties Tetrabenazine (C19H27NO3, Mr = 317.4 g/mol) is a benzoquinolizine derivative. Effects Tetrabenazine (ATC N07XX06) has indirect antidopaminergic and transmitter depleting properties. It inhibits the uptake of dopamine, norepinephrine, and serotonin into the salivary vesicles … Tetrabenazine