Products Sofosbuvir is commercially available in the form of film-coated tablets (Sovaldi). It was approved in the United States and EU in 2013 and in many countries in 2014. The very high price of the drug has been a source of debate. Sofosbuvir is also combined fixed with ledipasvir (Harvoni). Cheaper generics are available in … Sofosbuvir
Symptoms Most patients have no symptoms. The disease may manifest as fatigue, nausea, loss of appetite, muscle and joint pain, and weight loss. Potential longer-term dangerous complications of chronic infection that can develop over years include cirrhosis and liver cancer. This eventually often makes liver transplantation necessary. Causes The cause of the symptoms is infection … Hepatitis C Symptoms, Causes and Treatment
Products Velpatasvir was approved in 2016 in fixed combination with the HCV polymerase inhibitor sofosbuvir in film-coated tablet form (Epclusa, Gilead). Another fixed combination is Vosevi with sofosbuvir and voxilaprevir. Structure and properties Velpatasvir (C49H54N8O8, Mr = 883.0 g/mol) Effects Velpatasvir has antiviral properties. The effects are due to binding to the viral protein NS5A … Velpatasvir
Products Voxilaprevir is commercially available as film-coated tablets in fixed combination with sofosbuvir and velpatasvir (Vosevi). It was approved in the United States, many countries, and the EU in 2017. Structure and properties Voxilaprevir (C40H52F4N6O9S, Mr = 868.9 g/mol) Effects Voxilaprevir has antiviral properties. The effects are due to noncovalent and reversible inhibition of the … Voxilaprevir
