Products
Amylmetacresol and 2,4-dichlorobenzyl alcohol are commercially available as a combination preparation in the form of lozenges (Strepsils). The drug was approved in many countries in 2009. In the UK, it has been available for decades and is a well-known brand. The name “Strep “sils is derived from strep throat. 2,4-Dichlorobenzyl alcohol is also found in other lozenges for sore throats.
Structure and properties
Amylmetacresol (C12H18O, Mr = 178.3 g/mol) is an alkyl derivative of metacresol (3-methylphenol). Dichlorobenzyl alcohol (C7H6Cl2O, Mr = 177.0 g/mol) is a doubly chlorinated benzyl alcohol.
Effects
Amylmetacresol and 2,4-dichlorobenzyl alcohol (ATC R02AA03) has disinfectant properties against viruses, bacteria, fungi, and yeasts. It has also been shown to have analgesic effects in clinical studies. The drug information leaflet points out that in the case of bacterial infections (e.g. streptococcal angina), the need for targeted antibiotic therapy should be clarified. If a viral infection is suspected (e.g., oral thrush), the drug is not a causal therapy; if a fungal infection is suspected (e.g., oral thrush), treatment with an antifungal agent is required. The efficacy of disinfectants for the treatment of sore throat is generally controversial, but they may be symptomatically effective.
Indications
For adjuvant local therapy of infectious and inflammatory diseases of the mouth and throat, e.g., sore throat.
Contraindications
- Hypersensitivity
For complete precautions, see the drug label.
Interactions
Drug-drug interactions have not been reported to date.
Adverse effects
Hypersensitivity reactions may occur occasionally. Digestive symptoms such as nausea or dyspepsia are very rare.
Cf.
Flurbiprofen Lozenges
