Therapeutic target
Avert deterioration of renal function
Therapy recommendations
- Early initiation of immunosuppressive therapy:
- Glucocorticoids should be started first, as response to these can estimate prognosis
- Ciclosporin (cyclosporin A) is used in contraindications (contraindications) to glucocorticoids or steroid resistance.
- The immunosuppressant abatacept (rheumatoid drug) can stop proteinuria (increased excretion of protein in the urine) in patients with focal segmental glomerulonephritis (synonyms: focal and segmental hyalinosis and sclerosis, focal segmental glomerulosclerosis, FSGS) if the disease is associated with increased expression of the immune molecule B7-1 on podocytes (cells of the renal corpuscles) in the renal filters.
