Products
Benfotiamine is commercially available in Germany in the form of film-coated tablets, among others. It is usually combined fixed with vitamin B6 (pyridoxine). In many countries, benfotiamine is not registered.
Structure and properties
Benfotiamine (C19H23N4O6PS, Mr = 466.4 g/mol) is a lipophilic prodrug of thiamine (vitamin B1). It is dephosphorylated in the intestine to S-benzoylthiamine. S-benzoylthiamine is lipophilic and therefore diffuses better across cell membranes. Later, it is enzymatically metabolized to thiamine and converted to the active forms thiamine pyrophosphate (TPP) and thiamine triphosphate (TTP). Because of the double bond, two isomers exist (Figure: -isomer).
Effects
Benfotiamine (ATC A11DA03) is administered as a prodrug for vitamin B1. Thiamine plays an important role in carbohydrate metabolism and the nervous system as a cofactor (coenzyme) of enzymes.
Indications
For the treatment of vitamin B1 deficiency.
Dosage
According to the professional information leaflet.
Contraindications
Benfotiamine is contraindicated in cases of hypersensitivity. For complete precautions, see the drug label.
Interactions
An interaction with 5-fluorouracil has been described.
Adverse effects
Possible adverse effects include hypersensitivity reactions.
