Products Zidovudine is commercially available as film-coated tablets, capsules, and syrup (Retrovir AZT, combination products). It was approved in 1987 as the first AIDS drug. Structure and properties Zidovudine (C10H13N5O4, Mr = 267.2 g/mol) or 3-azido-3-deoxythymidine (AZT) is an analog of thymidine. It exists as an odorless, white to beige, crystalline substance that is soluble … Zidovudine (AZT)
Products Oxcarbazepine is available in the form of film-coated tablets, sustained-release tablets, and as a suspension and commercially (Trileptal, Apydan extent). It has been approved in many countries since 1997. Structure and properties Oxcarbazepine (C15H12N2O2, Mr = 252.3 g/mol) exists as a white to faint orange crystalline powder and is practically insoluble in water. Oxcarbazepine … Oxcarbazepine
Products Erdostein is commercially available in the form of capsules (Mucofor). It was developed at Edmond Pharma in Milan, Italy, and has been approved in many countries since 1994. Structure and properties Erdostein (C8H11NO4S2, Mr = 249.3 g/mol) is a prodrug. The effects are mediated by the free sulfhydryl groups (-SH) of the metabolites. The … Erdostein
Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products Azathioprine is commercially available as film-coated tablets and as a lyophilizate (Imurek, generic). It has been approved in many countries since 1965. Structure and properties Azathioprine (C9H7N7O2S, Mr = 277.3 g/mol) is a nitromidazole derivative of mercaptopurine. It exists as a pale yellow powder that is practically insoluble in water. Effects Azathioprine (ATC L04AX01) … Azathioprine (Imuran)
Products No drugs containing dihydroartemisinin are currently approved in many countries. However, the prodrug artemether (Riamet, with lumefantrine), which is metabolized in the body to dihydroartemisinin, is available. It is also combined fixed with piperaquine; see Piperaquine and Dihydroartemisinin. Structure and properties Dihydroartemisinin (C15H24O5, Mr = 284.3 g/mol) is derived from artemisinin from annual mugwort … Dihydroartemisinin
Products Quinapril is commercially available in the form of film-coated tablets as a monopreparation (Accupro) and as a fixed combination with hydrochlorothiazide (Accuretic, Quiril comp). It has been approved in many countries since 1989. Generic versions are registered. Structure and properties Quinapril (C25H30N2O5, Mr = 438.5 g/mol) is present in drugs as quinapril hydrochloride, a … Quinapril
Products Mitomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Mitem). Structure and properties Mitomycin (C15H18N4O5, Mr = 334.3 g/mol) exists as a blue-violet crystalline powder or as crystals and is sparingly soluble in water. It is formed by a strain of. Mitomycin was first isolated in … Mitomycin
Products Indoxacarb is commercially available as a drop-on solution for dogs and cats. It was approved in many countries in July 2012. Structure and properties Indoxacarb (C22H17ClF3N3O7, Mr = 527.8 g/mol) is a prodrug that is biotransformed to the active metabolite only in the insect by cleavage of the carbomethoxy group. It belongs to the … Indoxacarb
Products Stavudine is commercially available in capsule form (Zerit). It has been approved in many countries since 1996. Structure and properties Stavudine (C10H12N2O4, Mr = 224.2 g/mol) is a thymidine analog with a missing 3′-hydroxy group. It is a prodrug that is biotransformed intracellularly to the active metabolite stavudine triphosphate. Stavudine exists as a white … Stavudine
Products Abiraterone is commercially available in the form of film-coated tablets (Zytiga). It has been approved in many countries since 2011. Structure and properties Abiraterone acetate (C26H33NO2, Mr = 391.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a prodrug and is rapidly biotransformed in the body to … Abiraterone Acetate
Products Entecavir is commercially available as film-coated tablets and as an oral solution (Baraclude). It has been approved in many countries since 2006. Generic versions have been available since 2017. Structure and properties Entecavir (C12H15N5O3, Mr = 277.3 g/mol) is a 2′-deoxyguanosine nucleoside analog. It exists as a white powder that is sparingly soluble in … Entecavir
