Carpal Tunnel Syndrome: Drug Therapy

Therapy target

Improvement of symptomatology

Therapy recommendations

  • Anti-inflammatory drugs (non-steroidal anti-inflammatory drugs, NSAIDs), e.g., diclofenac, ibuprofen [no sustained significant effect!].
  • In the early stages of the disease: night splinting of the wrist and local infiltration of cortisone (glucocorticoids); as short and low doses as possible (e.g. once 20 mg methylprednisolone) Cave (Warning)! With infiltration (“insertion”; injection) with hydrocortisone, there is a risk of tendon rupture (tendon rupture)!
  • See also under “Further therapy“.

Further notes

  • Ibuprofen: increased cardiovascular risk was not observed at doses up to 1,200 mg per day.
  • In a study of 212 patients with mild to moderate carpal tunnel syndrome, the efficacy of a corticosteroid injection was compared with that of a wrist splint. After 6 weeks, a single corticosteroid injection was found to be more effective than wrist splint care.