Structure and properties
Daunorubicin (C27H29NO10, Mr = 527.5 g/mol)
Effects
Daunorubicin (ATC L01DB02) is a cytotoxic anthracycline antibiotic. It is isolated from cultures of various Streptomyces strains. By intercalation into DNA, it inhibits topoisomerase II and thereby nucleic acid and protein synthesis and cell division.
Indications
- Leukemia
- Hodgkin’s disease
- Neuroblastoma
