Structure and properties Daunorubicin (C27H29NO10, Mr = 527.5 g/mol) Effects Daunorubicin (ATC L01DB02) is a cytotoxic anthracycline antibiotic. It is isolated from cultures of various Streptomyces strains. By intercalation into DNA, it inhibits topoisomerase II and thereby nucleic acid and protein synthesis and cell division. Indications Leukemia Hodgkin’s disease Neuroblastoma
Products Epirubicin is commercially available as a concentrate for injection/instillation (farmorubicin, generics). It has been approved in many countries since 1993. Structure and properties Epirubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to doxorubicin. Effects Epirubicin (ATC L01DB03) is antineoplastic. It is an anthracycline antibiotic, rapidly penetrates the cell, binds to DNA, and … Epirubicin
Products Mitoxantrone is commercially available as an infusion/injection solution (Novantrone, generic). It has been approved in many countries since 1985. Structure and properties Mitoxantrone (C22H28N4O6, Mr = 444.5 g/mol) Effects Mitoxantrone (ATC L01DB07) has cytotoxic and immunosuppressive properties. The effects are due to inhibition of topoisomerase II and intercalation of DNA. Indications Carcinomas, lymphomas, leukemia … Mitoxantrone
Products Idarubicin is commercially available in capsule form and as a solution for injection (Zavedos, generics). It has been approved in many countries since 1992. Structure and properties Idarubicin (C26H27NO9, Mr = 497.5 g/mol) Effects Idarubicin (ATC L01DB06) is a cytotoxic anthracycline antibiotic. It inhibits topoisomerase II by intercalation into DNA, thereby inhibiting nucleic acid … Idarubicin
Products Doxorubicin is commercially available as an injectable (Adriblastin, generic). It has been approved in many countries since 1989. Caelyx is a pegylated and liposomal formulation of the drug and was registered in 1997. Myocet is a liposomal and nonpegylated formulation. Structure and properties Doxorubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to … Doxorubicin
