TNM classification of esophageal carcinomas and included carcinomas of the esophagogastric junction.
T | Infiltration depth of the tumor |
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
Tis | Carcinoma in situ |
T1a | Infiltration of the lamina propria |
T1b | Infiltration of the submucosa |
T2 | Infiltration of the muscularis propria |
T3 | Infiltration of the Adventitia |
T4 | Infiltration of neighboring structures |
T4a | Tumor infiltrates pleura (lung pleura), pericardium (heart pleura), diaphragm |
T4b | Tumor infiltrates other adjacent structures such as aorta, vertebral body, or trachea (windpipe) |
N | Lymph node metastases (daughter tumors in the lymph nodes) |
NX | Regional lymph nodes cannot be assessed |
N0 | No regional lymph node metastases |
N1 | Metastases in 1-2 lymph nodes |
N2 | Metastases in 3-6 lymph nodes |
N3 | Metastases in 7 or more regional lymph nodes |
M | Metastases |
M0 | No metastases |
M1 | Distant metastases |
pTNM: Pathological classification (The pT and pN categories correspond to the T and N categories).
- PM1 – distant metastases
- PN0 – Regional lymphadenectomy (lymph node removal) and histologic (fine tissue) examination usually of 7 or more lymph nodes.
Note: pM0 and pMX are not applicable categories.
TNM classification for staging.
Stage | T | N | M |
0 | Tis | N0 | M0 |
IA | T1 | N0 | M0 |
IB | T2 | N0 | M0 |
IIA | T3 | N0 | M0 |
IIB | T1, T2 | N1 | M0 |
IIIA | T4a | N0 | M0 |
T3 | N1 | M0 | |
T1, T2 | N2 | M0 | |
IIIB | T3 | N2 | M0 |
IIIC | T4a | N1, N2 | M0 |
T4b | each N | M0 | |
each T | N3 | M0 | |
IV | T1-4 | each N | M1 |
Tumor regression score for adenocarcinomas according to Becker et al.
Regression score | Definition |
1a | complete regression |
1b | Subtotal regression (1-50% residual tumor/ tumor bed). |
2 | Partial regression (10-50% residual tumor/ tumor bed). |
3 | Low/no regression (>50% residual tumor/ tumor bed). |