Products
Fusidic acid eye drop gel has been approved in many countries since 1993 (Fucithalmic).
Structure and properties
Fusidic acid (C31H48O6, Mr = 516.7 g/mol) belongs to the steroid antibiotics. It is obtained by fermentation from certain strains of or produced by other processes. The antibiotic exists as a white crystalline powder and is practically insoluble in water.
Effects
Fusidic acid (ATC S01AA13) has bactericidal properties. It is predominantly effective against Gram-positive bacteria, for example, staphylococci and streptococci. The effects are based on inhibition of bacterial protein synthesis.
Indications
For the treatment of bacterial eye infections caused by susceptible germs, especially bacterial conjunctivitis.
Dosage
According to the SmPC. One drop of the dropper gel is placed in the conjunctival sac every 12 hours. More frequent administration is recommended at the start of treatment, for example, every four hours on the first day. When symptoms have subsided, treatment should be continued for two days. Contact lenses should not be worn during therapy.
Contraindications
Fusidic acid is contraindicated in cases of hypersensitivity. For complete precautions, see the drug label.
Adverse Effects
The most common possible adverse effects include reactions in or around the eye such as pain, itching, irritation, discomfort, and blurred vision.