General symptoms and pathophysiology (pathogenesis)

Symptoms of anaemia

In general, anemia initially manifests itself through rather unspecific characteristics such as fatigue and weakness. Headaches and dizziness or ringing in the ears (tinnitus) can also occur. Those affected are pale, easily recognizable by the conjunctiva of the eye or the bed of the nails.

A pale facial colour in itself is rather an uncertain sign. Very mild forms of anaemia sometimes even remain without symptoms. Depending on the severity of the anaemia or the speed at which the anaemia develops, the affected person will suffer from an accelerated heartbeat (tachycardia) and an increased blood pressure amplitude, i.e. the difference between the upper (systolic) value and the lower (diastolic) value when measuring blood pressure.

Origin of the disease

Some patients with anemia also stand out due to functional heart murmurs. The doctor uses a stethoscope to hear a heart murmur while the heart pumps the blood, but this usually disappears as soon as the anaemia is resolved and there are no heart murmurs due to other diseases. The strain on the heart can go as far as heart failure.

Characteristics are shortness of breath (dyspnoea), water retention (edema) and nocturnal urination (nocturia). The shortness of breath initially manifests itself only under exertion, in the advanced stage also at rest. In severe cases, the tissue (hypoxia), the brain, the heart (angina pectoris) or the legs (claudication) are undersupplied with oxygen. Certain forms of anaemia are accompanied by the symptom of yellowing of the eyes and skin (icterus = jaundice). Ferritin