Synonyms Malignant hyperpyrexia, MH crisis Introduction The full picture of malignant hyperthermia is a very serious metabolic derailment that occurs almost exclusively in connection with anesthesia. Here, a disorder in the calcium balance of the muscle cell, which is symptom-free in everyday life, leads to a massive disturbance of the overall metabolism after contact with … Malignant hyperthermia
What are trigger substances? The trigger substances of malignant hyperthermia, i.e. substances that can trigger this functional disorder, are Inhalation anesthetics, succinylcholine and also caffeine. Inhalation anesthetics, such as sevoflurane, are used to induce and maintain anesthesia. An exception is nitrous oxide, which is a safe substance and not a trigger for malignant hyperthermia. Succinylcholine … What are trigger substances? | Malignant hyperthermia
Therapy Of utmost importance for the therapy is the immediate stop of the supply of the triggering substance and, if necessary, the change to another anaesthetic procedure. By administering the drug dantrolene, the disease mechanism can be interrupted. An operation already in progress should be terminated as soon as possible. The oxygen supply is increased, … Therapy | Malignant hyperthermia