Products Glibenclamide is commercially available in tablet form (Daonil, generics). It has been approved in many countries since 1970 and is also used in fixed combination with metformin (Glucovance). Structure and properties Glibenclamide (C23H28ClN3O5S, Mr = 494.0 g/mol) is a sulfonylurea. It exists as a white crystalline powder that is practically insoluble in water. Effects … Glibenclamide
Products Glibornuride was commercially available in tablet form (Glutril, originally Roche, later MEDA Pharma). It was approved in many countries since 1971. It was discontinued in 2019. Structure and properties Glibornuride (C18H26N2O4S, Mr = 366.48 g/mol) is a sulfonylurea. Effects Glibornuride (ATC A10BB04) has antihyperglycemic and antidiabetic properties. The effects are due to the promotion … Glibornuride
Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide
Products Glimepiride is commercially available in tablet form (Amaryl, generic). It has been approved in many countries since 1995. Structure and properties Glimepiride (C24H34N4O5S, Mr = 490.62 g/mol) exists as a white to yellowish-white, crystalline and odorless powder that is practically insoluble in water. It belongs structurally to the sulfonylureas. Effects Glimepiride (ATC A10BB12) has … Glimepiride
Products Glibenese is no longer commercially available in many countries. Numerous other sulfonylureas and antidiabetic agents are available as alternatives. Structure and properties Glipizide (C21H27N5O4S, Mr = 445.54 g/mol) is a white to almost white crystalline powder that is practically insoluble in water. Effects Glipizide (ATC A10BB07) is antidiabetic; see under sulfonylureas. Indications Type II … Glipizide
Products Chlorpropamide was commercially available in many countries in tablet form as a fixed combination with metformin (Diabiformin). The drug was approved in 1971 and is no longer available. Structure and properties Chlorpropamide (C10H13ClN2O3S, 276.74 g/mol) is a white crystalline powder that is practically insoluble in water. Effects Chlorpropamide (ATC A10BB02) has antidiabetic properties. Indications … Chlorpropamide
