Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Products Darvadstrocel was approved in the EU and many countries in 2018 in the form of an injection suspension (Alofisel). The suspension contains 5 million live cells per milliliter. Structure and properties These are expanded, human, allogeneic (from another individual), mesenchymal, adult stem cells derived from adipose tissue. In English, they are referred to as … Darvadstrocel
Products Andexanet alfa was approved in the United States in 2018, in the EU in 2019, and in many countries in 2020 as a powder for the preparation of an infusion solution (Ondexxya). Structure and properties Andexanet alfa is a recombinant, modified, and enzymatically inactive factor Xa. The drug is produced by biotechnological methods. Effects … Andexanet Alfa
Products The first therapeutic monoclonal antibody was approved in 1986. Muromonab-CD3 (Orthoclone OKT3) binds to the CD3 receptor on T cells and has been used in transplantation medicine. Numerous drugs containing antibodies are now available. A selection of active substances can be found at the end of this article. These are expensive drugs. For example, … Monoclonal Antibodies
Products Therapeutic proteins are usually administered in the form of injection and infusion preparations and must be stored in a refrigerator. The first recombinant protein to be approved was human insulin in 1982. Some proteins, for example, are also available in tablet, capsule, and powder form and can be stored at room temperature, such as … Therapeutic Proteins
Products VEGF inhibitors are commercially available as injectables from various suppliers. The first agent in this group to be approved was pegaptanib (Macugen) in 2004, which is now off the market in many countries. Structure and properties The currently available VEGF inhibitors are therapeutic proteins (biologics). They are antibodies, antibody fragments, and fusion proteins. They … VEGF Inhibitors
Products Vaccines are mainly sold as injectables. Some are also taken perorally as oral vaccines, for example, in the form of capsules (typhoid vaccine) or as a suspension for oral administration (rotavirus). Monopreparations and combination preparations are commercially available. Vaccines, with few exceptions, are stored in a refrigerator at a temperature of 2 to 8 … Vaccines
