Products Lacidipine was commercially available in the form of film-coated tablets (Motens, off label). It was approved in many countries since 1992. Distribution was discontinued in 2016. Structure and properties Lacidipine (C26H33NO6, Mr = 455.5 g/mol) is a lipophilic dihydropyridine and structurally related to the precursor nifedipine. Effects Lacidipine (ATC C08CA09) is vasodilator and antihypertensive. … Lacidipine
Products Mibefradil (Posicor tablets) was launched in many countries in 1996 and withdrawn from the market in 1998 because of potential interactions. It is no longer commercially available. Structure and properties Mibefradil (C29H38FN3O3, Mr = 495.6 g/mol) is a benzimidazole and a tetralol derivative. It is present in drugs as mibefradildihydrochloride. Effects Mibefradil (ATC C08CX01) … Mibefradil
Products Flunarizine is commercially available in tablet form (Sibelium). It has been approved in many countries since 1979. Structure and properties Flunarizine (C26H26F2N2, Mr = 404.49 g/mol) is present in drugs as flunarizine dihydrochloride, a white powder that is sparingly soluble in water. Effects Flunarizine (ATC N07CA03) has antivertiginous and depressant properties. It is a … Flunarizine: Drug Effects, Side Effects, Dosage and Uses
Products Clevidipine is marketed as an oil-in-water emulsion for intravenous injection (Cleviprex). It was approved in the United States in 2008 and in many countries in 2010. It is also registered in several European countries. Structure and properties Clevidipine (C21H23Cl2NO6, Mr = 456.32 g/mol) is a racemate of – and -levidipine. Both enantiomers are involved … Clevidipine
